Does varicocelectomy affect DNA fragmentation in infertile patients?

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AB191. Varicocelectomy decreases sperm DNA fragmentation index in infertile men

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Multiple Determinations of Sperm DNA Fragmentation Show That Varicocelectomy Is Not Indicated for Infertile Patients with Subclinical Varicocele

Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were per...

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Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility

BACKGROUND Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to evaluate the parameters of semen and the DNA fragmentation index (DFI) in pat...

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P-193: Chlamydia Trachomatis Can Increase Sperm DNA Fragmentation in Infertile Men

Background: Chlamydia Trachomatis (CT) is an obligate intracellular bacteria, that requires living cells to replicate itself and is responsible for lower urinary tract disease in men and women. It can cause urethritis, epididymitis, orchitis and complications such as chronic prostatitis in men. Chlamydia infections may also directly affect male fertility by damaging the sperm, because sperm par...

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The impact of coexisting sperm DNA fragmentation and seminal oxidative stress on the outcome of varicocelectomy in infertile patients: A prospective controlled study

OBJECTIVES To study the relationship between sperm DNA fragmentation (SDF) and reactive oxygen species (ROS) levels in infertile patients with varicocele, and to examine the beneficial effect of varicocelectomy and elucidate predictors of improvement after repair. PATIENTS SUBJECTS AND METHODS We prospectively studied 60 patients with varicocele and abnormal semen variables who attended the o...

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ژورنال

عنوان ژورنال: Indian Journal of Urology

سال: 2015

ISSN: 0970-1591

DOI: 10.4103/0970-1591.152811